Plasma amyloid β levels in Alzheimer’s disease and cognitively normal controls in Syrian population
نویسندگان
چکیده
منابع مشابه
Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals
INTRODUCTION Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. METHODS Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifesty...
متن کاملPlasma β-amyloid in Alzheimer’s disease and vascular disease
Implementation of amyloid biomarkers in clinical practice would be accelerated if such biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a cohort of 719 individuals (the Swedish BioFINDER study), including patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), Alzheimer's disease (AD) dementia and cognitively healthy elderly, using ...
متن کاملCognitive impairment and decline in cognitively normal older adults with high amyloid-β: A meta-analysis
INTRODUCTION This meta-analysis aimed to characterize the nature and magnitude of amyloid (Aβ)-related cognitive impairment and decline in cognitively normal (CN) older individuals. METHOD MEDLINE Ovid was searched from 2012 to June 2016 for studies reporting relationships between cerebrospinal fluid or positron emission tomography (PET) Aβ levels and cognitive impairment (cross-sectional) an...
متن کاملIncreased levels of plasma amyloid-beta are related to cortical thinning and cognitive decline in cognitively normal elderly subjects.
Plasma levels of circulating amyloid-beta (Aβ) peptides are of particular interest in Alzheimer' disease, but little is known about cognitive and cortical correlates of peripheral Aβ levels in normal aging. Here, we compared cognitive functioning, vascular risk factors, and patterns of cortical thickness between cognitively intact elderly subjects with low (N = 60) and high (N = 60) plasma Aβ l...
متن کاملPredicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls.
IMPORTANCE Alzheimer disease has a long preclinical stage characterized by β-amyloid (Aβ) accumulation without symptoms. Several trials focus on this stage and use biomarkers to include Aβ-positive participants, but an even earlier prevention of Aβ accumulation may be an effective treatment strategy. OBJECTIVE To determine whether people who appear to be Aβ negative but are at high risk for A...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Journal of The Islamic Republic of Iran
سال: 2021
ISSN: 1016-1430,2251-6840
DOI: 10.47176/mjiri.35.19